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Devastating Blow: 49ers Lose Nick Bosa for "Multiple Weeks" After Calf Strain in Practice

Kyle Shanahan confirms the All-Pro pass rusher will be sidelined through October in a massive setback for San Francisco's defensive front.

NewsWebWire
NewsWebWire Sports Desk
Published Sep 26, 2026, 11:55 AM
Devastating Blow: 49ers Lose Nick Bosa for "Multiple Weeks" After Calf Strain in Practice
Photo: All-Pro Reels / Wikimedia Commons (CC BY-SA 2.0)1200×675 HD

Key Story Takeaways

  • MRI imaging confirmed a Grade 2 calf strain sustained during Friday team drills.
  • San Francisco expects Bosa to miss between three and four games, targeting a late October return.
  • Veteran pass rusher Leonard Floyd and interior anchor Javon Hargrave will shoulder expanded pass-rush reps.
  • Shanahan stressed the team will handle Bosa's recovery conservatively to prevent Achilles aggravation.

SANTA CLARA — Just when the San Francisco 49ers appeared to be finding their rhythm, the injury bug delivered another crushing punch to Levi's Stadium.

Head coach Kyle Shanahan confirmed Saturday morning that reigning Defensive Player of the Year Nick Bosa sustained a calf strain during Friday's practice session that will keep him off the field for "multiple weeks."

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Bosa pulled up suddenly during non-contact team drills, clutching the back of his lower leg. An MRI confirmed moderate muscle fiber damage, wiping out San Francisco's top defensive weapon for critical upcoming divisional tests.

Kyle Shanahan: "We Are Not Rushing Him Back"

Addressing the press at the SAP Performance Facility, Shanahan gave an honest assessment of the timeline:

"Nick felt something grab in his calf during team drills. We had him undergo an MRI, and it confirmed a strain that will put him down for multiple weeks. We are not rushing him back. Calf injuries are tricky, and you don't mess around with them."

Defensive captain and All-Pro linebacker Fred Warner spoke on the mood in the locker room:

"Nick is the engine of this defensive front. Nobody replaces what 97 brings to this defense, but the standard doesn't drop. Everyone on that line has to elevate their play."

How San Francisco Replaces #97

Without Bosa commanding constant double-teams and chips, defensive coordinator Nick Sorensen must re-tool his rush packages. Expect newly acquired Leonard Floyd to take over primary edge duties on passing downs, with expanded interior stunts designed to free up Javon Hargrave.

#49ers#Nick Bosa#Injuries#Kyle Shanahan#NFC West